Risk Factors Modifying Familial Aggregation for Lung Cancer in Affected Individual

Authors

Keywords:

familial aggregation, lung cancer, risk factors, epidemiology.

Abstract

Introduction: Oncologic diseases are considered multifactorial and have a complex hereditary component (multiple involved genes interact with each other, as well as with environmental phenomenons), have a global distribution and affect an increasing number of individuals. Lung cancer is a disease with a high global incidence.

Objective: To determine the risk factors that modify familial aggregation for lung cancer.

Methods: A longitudinal, retrospective and case-control study was carried out with the population of Banes Municipality, Holguin Province, from October 2022 to March 2023. The universe included 133 diagnosed individuals and their families. The sample was obtained by simple random sampling (72 cases) and the control group was formed at a 3:1 ratio (216 individuals with no history of disease). Bioethical requirements were met. Inclusion and exclusion criteria were applied. The following statistics were used: chi-square, odds ratio (OR), as well as p and confidence interval. The variables age, degree of consanguinity and risk factors were determined. The family tree was obtained.

Results: Relatives with first and second degrees of consanguinity showed the highest incidence of the disease. The age group 70 years and older prevailed. Familial aggregation was demonstrated for the disease (X2 = 28.38, OR = 5.19, CI 95 % [2.65, 1 0.17]). Age older than 40 years (87.1 %) and dyspnea (87.5 %) were remarkable clinical aspects. Risk factors showed association for the disease (X2 = 23.64, p ≤ 0.05). Smoking (X2 = 3, OR = 1.12, CI 95 % [0.99, 1.27]) and history of chronic lung disease (X2 = 124.1, OR = 0.48, CI 95 % [0.42, 0.55]) expressed highly significant association for lung cancer.

Conclusions: Smoking and family history of the disease came to be the risk factors that modified familial aggregation for lung cancer.

 

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Author Biographies

Julio Armando Sánchez Delgado, Centro Municipal de Genética Comunitaria- Banes

Especialista de 2do grado en Medicina General Integral, Máster en Asesoramiento Genético y Educación Médica, Profesor Auxiliar, Investigador Agregado

Nailé Edita Sánchez Lara, Filial Ciencias Médicas Urselia Díaz Báez.- Banes- Holguín

Estudiante. Carrera Medicina. Sexto Año. Alumna Ayudante en Medicina General Integral

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Published

2024-11-11

How to Cite

1.
Sánchez Delgado JA, Sánchez Lara NE, Morales Peralta E, Santana Hernández EE. Risk Factors Modifying Familial Aggregation for Lung Cancer in Affected Individual. Rev cuba med gen integr [Internet]. 2024 Nov. 11 [cited 2025 Apr. 3];40(1). Available from: https://revmgi.sld.cu/index.php/mgi/article/view/3093

Issue

Vol. 40 (2024): publicación continua

Section

ARTÍCULOS ORIGINALES

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