Risk Factors that Modify Familial Aggregation for Ischemic Cardiovascular Disease

Authors

Keywords:

risk factors, ischemic cardiovascular disease, familial aggregation, epidemiology.

Abstract

Introduction: Ischemic cardiovascular disease is a global health problem.

Objective: To determine the risk factors that modify familial aggregation for ischemic cardiovascular disease in affected individuals.

Methods: A longitudinal and retrospective case-control research was carried out based on the population of the Banes municipality, Holguín province, from May 2020 to May 2022. The universe included 273 diagnosed individuals and their families. By simple random sampling, a sample of 149 cases was obtained and the control group was made up at a ratio of 3:1 (447 individuals with no history of disease). Bioethical requirements were met. Inclusion/exclusion criteria were applied. The following statistics were used: chi square, odds ratio (OR), including p and confidence interval. The following variables were operationalized: age, degree of consanguinity and risk factors.

Results: Relatives of first and second degree of consanguinity showed the highest incidence of disease. The 60-69 age group was the most affected. Familial aggregation was demonstrated for the disease (X2 = 45.93; OR = 5.85; CI 99.9 % (3.29; 10.41)). Ischemic cardiomyopathy (43.3%) and arrhythmias (20.7%) were remarkable forms of presentation. Risk factors showed association for the disease (X2 = 67.11; p ≤ 0.001). Arterial hypertension (X2 = 57.9; OR = 3.04; CI 99.9 % (2.27, 4.06)) and smoking (X2 = 45.7; OR = 2.66; CI 99.9 % (2.3, 5.6)) expressed a highly significant association for ischemic cardiovascular disease.

Conclusions: As risk factors, hypertension, smoking and family history modified familial aggregation for ischemic cardiovascular disease.

 

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Author Biography

Nailé Edita Sánchez Lara, Universidad de Ciencias Médicas de Holguín. Filial Ciencias Médicas Urselia Díaz Báez. - Banes

Estudiante, Carrera Medicina, Sexto Año, Alumna Ayudante en Medicina General Integral

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Published

2024-06-27

How to Cite

1.
Sánchez Delgado JA, Sánchez Lara NE. Risk Factors that Modify Familial Aggregation for Ischemic Cardiovascular Disease. Rev cuba med gen integr [Internet]. 2024 Jun. 27 [cited 2025 Apr. 3];40(1). Available from: https://revmgi.sld.cu/index.php/mgi/article/view/2989

Issue

Vol. 40 (2024): publicación continua

Section

ARTÍCULOS ORIGINALES

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